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Medications to Improve Bone Health

Metastatic prostate cancer commonly spreads to the bones, where it can cause bone pain and brittle-bone disease (osteoporosis). These symptoms can also arise during hormone therapy, when levels of testosterone are very low due to androgen deprivation therapy (ADT). The bones of men who take ADT may become thinner, more brittle and at increased risk for breaking. Your physician may prescribe medications, which can reduce bone loss that may result from hormone therapy, reduce the spread of cancer in the bone, alleviate pain and minimize other complications of bone metastases.

Type of Medications

  • Denosumab (Xgeva®) is used for prostate cancer patients with metastatic bone disease to prevent fractures, severe bone pain, and spinal cord compression. This treatment is given to patients in an ambulatory surgical center or a hospital. Xgeva contains denosumab, a protein (monoclonal antibody) that works to slow down bone destruction caused by cancer spreading to the bone (bone metastasis). Xgeva is used in adults with cancer to prevent serious complications caused by bone metastasis (e.g., fracture, pressure on the spinal cord, or the need for radiation therapy or surgery). Xgeva is administered as a single injection under the skin once every four weeks.
  • Denosumab (Prolia®) is used to increase bone mass in men with non-metastatic prostate cancer who are receiving hormonal therapy and are at high risk for fracture. This treatment is given to patients in an ambulatory surgical center or a hospital. Prolia contains denosumab, a protein (monoclonal antibody) that works to reduce the incidence of vertebral fractures. Prolia is administered once every six months, as a single injection under the skin (subcutaneous).

Treatment Options for Advanced Prostate Cancer

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Appointments & Information

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